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Major design parameters of polymeric matrices used in cytokine theraapies and their applications. Polymeric matrices can have varied properties by altering (i) the polymer composition, (ii) the resulting water content, and (iii) the type of crosslinker and/or conjugation. These matrices have been primarly used as (a) depots, (b) to promote endogenous cell recruitment, and (c) as exogenous cell resevoirs. Red arrows indicate progression of polymeric matrix systems after administration.
