TABLE 5.

Putative transport proteins^a

Rv no.	Product annotation	AA (%)	PDB macromolecule name	PDB ID	TM-score	TMADJ
Rv1085c	Putative membrane transporter receptor protein	0.073	Chloride-pumping rhodopsin	5b2nA	0.71	0.59
		0.058	Sodium-pumping rhodopsin	4xtlA	0.71	0.59
Rv1462	Putative transporter	0.173	ABC transporter, ATP-binding protein	4dn7A	0.79	0.67
Rv1510	Putative Na+/H+ antiporter drug efflux protein	0.104	Putative drug/sodium antiporter	4z3nA	0.89	0.60
		0.088	Multiantimicrobial extrusion protein [Na(+)/drug antiporter] MATE-like MDR efflux pump	3mktA	0.84	0.54
Rv1680	Putative phosphonate transporter component	0.151	PhnD, subunit of alkylphosphonate ABC transporter	3p7iA	0.91	0.77
		0.165	Binding protein component of ABC phosphonate transporter	3n5lA	0.89	0.76
Rv2325c	Putative transport protein	0.165	Putative cobalt ABC transporter, permease protein	5d3mD	0.87	0.60
		0.215	Energy-coupling factor transporter transmembrane protein EcfT	4huqT	0.81	0.54
Rv2508c	Putative MFS membrane transporter	0.104	Solute carrier family 2, facilitated glucose transporter member 3	5c65A	0.79	0.63
		0.119	d-Xylose-proton symporter	4gbyA	0.78	0.63
Rv3630	Putative Na+/H+ antiporter drug efflux protein	0.087	Multiantimicrobial extrusion protein [Na(+)/drug antiporter] MATE-like MDR efflux pump	3mktA	0.84	0.63
		0.108	Putative drug/sodium antiporter	4z3nA	0.83	0.62

^aMatches between proteins encoded by underannotated genes (Locus) and transport protein structure entries in Protein Data Bank (PDB). Only matches undescribed as transport proteins on UniProt are included (see Data Set S3E for all such matches). The top two matches are shown, if they exceed the adjusted TM-score (TM_ADJ) of >0.52 (the TM-score corresponding to matching topologies >50% of the time). AA% refers to the amino acid identity shared between the aligned region of the protein in M. tuberculosis and its match on PDB. MFS, major facilitator superfamily; MDR, multidrug resistance.