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. 2021 Oct 28;9(11):e002970. doi: 10.1136/jitc-2021-002970

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Antitumor activity of Toxoplasma gondii ΔGRA17 and programmed death ligand-1 (PD-L1) blockade therapy depends on CD8⁺ and natural killer (NK) cells. (A) Schematic showing the experimental protocol, including timeline for inoculation of B16-F10 cells, treatment with phosphate buffered saline (PBS) or ΔGRA17, and depletion of CD4⁺, CD8⁺, and NK cells using monoclonal antibodies. (B) Survival plot of mice that received the depleting antibodies before tumor implantation. (C) Survival plot of mice that received the depleting antibodies on day 0 of therapy. The survival of tumor-bearing mice (n=8 mice/group) was presented as Kaplan-Meier plots and tested for significance using log-rank tests. Student’s t-test, ***p<0.001, n/s, not significant compared with the indicated control.

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