(b) Parameters in equations (1)–(5) that were fitted to the respective refined occupancy values of CEF and P_i. The comparison of observed and calculated occupancies allows the determination of a diffusion coefficient D _eff.

BlaC–CEF increase, (1)		Pi decrease, (2)	BlaC–CEF in the crystal center, (5)
Observed†		Observed†	Sigmoidal increase‡		D (cm2 s−1) for CEF, (3) and (4)
C S,CEF	τ1/2 (ms)	τ1/2 (ms)	k (ms−1)	t 0 (ms)	Water	D eff §
88%	4.6	6.7	0.3	13.1	2.3 × 10−6	2 × 10−7