Table 2.

Univariate and multivariate Cox regression analyses of overall survival in the datasets.

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI of HR	p-value	HR	95%CI of HR	p-value
TCGA
lncRNAsig (high/low)	1.996	1.513–2.633	<0.001	2.214	1.669–2.939	<0.001
Age	1.021	1.008–1.033	<0.001	1.024	1.011–1.037	<0.001
Gender (male/female)	0.751	0.563–1.000	0.050	0.798	0.594–1.073	0.136
TNM stage (I/II vs. III/IV)	1.216	0.877–1.685	0.242	1.259	0.906–1.748	0.170
GSE41613
lncRNAsig (high/low)	2.185	1.230–3.882	0.008	1.76812	0.980–3.192	0.059
Age group a	0.924	0.689–1.239	0.598	0.9365	0.685–1.281	0.681
Gender (male/female)	1.123	0.621–2.029	0.702	1.11925	0.618–2.029	0.710
TNM stage (I/II vs. III/IV)	3.829	1.959–7.485	<0.001	3.36525	1.699–6.666	<0.001
GSE42743
lncRNAsig (high/low)	1.892	1.019–3.512	0.043	1.91053	1.003–3.641	0.049
Age	1.004	0.980–1.028	0.764	1.013	0.988–1.038	0.305
Gender (male/female)	0.676	0.337–1.355	0.270	0.56938	0.281–1.154	0.118
TNM stage (I/II vs. III/IV)	2.917	1.210–7.034	0.017	3.09155	1.259–7.590	0.014
FUSCC
lncRNAsig (high/low)	2.636	1.132–6.137	0.025	2.4945	1.058–5.881	0.037
Age	1.016	0.971–1.063	0.505	1.0137	0.967–1.063	0.574
Gender (male/female)	0.751	0.256–2.205	0.602	0.8999	0.301–2.695	0.851
TNM stage (I/II vs. III/IV)	2.276	0.777–6.667	0.134	2.3862	0.801–7.107	0.118

HR, hazard ratio; CI, confidence interval; lncRNAsig, long non-coding RNA signature; TCGA, The Cancer Genomics Atlas; TNM, tumor node metastasis; FUSCC, Fudan University Shanghai Cancer Center.

^aAge groups: 19–39 years, 40–49 years, 50–59 years, and 60–68 years.

Bold type indicates statistical significance.