Table 1.
Bivariate associations of patient factors with latent trajectory classes (N = 270)
| Overall N = 270 |
1: Stable Low N = 178 (66%) |
2: Increasing N = 25 (9%) |
3: Reactive N = 21 (8%) |
4: Decreasing N = 10 (4%) |
5: Stable High N = 36 (13%) |
Omnibus p-value |
Pairwise comparisons with p<0.05 |
|
|---|---|---|---|---|---|---|---|---|
| Demographic and general health | ||||||||
| Age: mean (SD) | 56 (11) | 57 (11) | 55 (13) | 55 (13) | 51 (11) | 54 (9) | .24 | |
| BMI: mean (SD) | 24.4 (5.8) | 25.4 (6.0) | 25.6 (5.1) | 24.5 (5.5) | 24.5 (7.1) | 26.1 (5.5) | .89 | |
| Race/ethnicity | .37 | |||||||
| White | 203 (75) | 133 (75) | 18 (72) | 16 (76) | 8 (80) | 28 (78) | ||
| Black | 12 (4) | 6 (4) | 4 (16) | 1 (5) | 1 (10) | 0 (0) | ||
| Asian | 30 (11) | 23 (13) | 2 (8) | 2 (10) | 0 (0) | 3 (8) | ||
| Other | 25 (9) | 16 (9) | 1 (4) | 2 (10) | 1 (10) | 5 (14) | ||
| Income | .80 | |||||||
| Under $60K | 67 (25) | 39 (22) | 7 (29) | 7 (35) | 3 (33) | 11 (31) | ||
| $60-100K | 53 (20) | 34 (19) | 5 (21) | 3 (15) | 2 (22) | 9 (24) | ||
| $100K or more | 146 (55) | 104 (59) | 12 (50) | 10 (50) | 4 (44) | 16 (44) | ||
| Education | .063 | 2 vs 3 (p=.026) | ||||||
| College or less | 186 (69) | 120 (67) | 13 (52) | 18 (86) | 6 (60) | 29 (81) | 2 vs 5 (p=.025) | |
| Postgraduate | 84 (31) | 58 (33) | 12 (48) | 3 (14) | 4 (40) | 7 (19) | ||
| Employed | 161 (60) | 110 (62) | 16 (64) | 11 (52) | 4 (40) | 20 (56) | .58 | |
| Partnered | 174 (64) | 115 (65) | 12 (48) | 14 (67) | 8 (80) | 25 (69) | .35 | |
| Children at home | 189 (70) | 124 (70) | 15 (60) | 16 (76) | 8 (80) | 26 (72) | .71 | |
| Charlson Co-morbidity Scale: mean (SD) | 0.31 (0.62) | 0.30 (0.63) | 0.28 (0.46) | 0.24 (0.44) | 0.10 (0.32) | 0.47 (0.81) | .41 | |
| Godin Physical Activity Scale: median (IQR) | 21 (9-38) | 25 (13-41) | 21 (12-35) | 14 (6-29) | 14.5 (0-36) | 18 (9-37) | .18 | |
| Menopausal status at baseline | .44 | |||||||
| Pre- or perimenopausal | 84 (31) | 49 (28) | 9 (36) | 11 (52) | 4 (40) | 11 (31) | ||
| Postmenopausal | 170 (63) | 119 (67) | 14 (56) | 9 (43) | 6 (60) | 22 (61) | ||
| Hysterectomy | 16 (6) | 10 (6) | 2 (8) | 1 (5) | 0 (0) | 3 (8) | ||
| Disease and treatment-related | ||||||||
| Stage: | .06 | 1 vs 5 (p=.008) | ||||||
| 0 or I | 160 (62) | 95 (57) | 14 (56) | 14 (67) | 8 (80) | 29 (81) | 2 vs 5 (p=.049) | |
| II or III | 99 (38) | 72 (43) | 11 (44) | 7 (33) | 2 (20) | 7 (19) | ||
| Surgery, eventual | .08 | 1 vs 5 (p=.015) | ||||||
| None or lumpectomy | 159 (59) | 110 (62) | 15 (60) | 15 (71) | 5 (50) | 14 (39) | 3 vs 5 (p=.028) | |
| Mastectomy | 110 (41) | 67 (38) | 10 (40) | 6 (29) | 5 (50) | 22 (61) | ||
| Receipt of chemotherapy | .16 | |||||||
| None | 172 (64) | 109 (62) | 14 (56) | 13 (62) | 8 (80) | 28 (78) | ||
| Adjuvant | 73 (27) | 51 (29) | 11 (44) | 6 (29) | 1 (10) | 4 (11) | ||
| Neoadjuvant | 25 (9) | 17 (10) | 0 (0) | 2 (10) | 1 (10) | 4 (11) | ||
| Receipt of radiation | 183 (69) | 122 (69) | 16 (64) | 19 (90) | 5 (50) | 21 (58) | .08 | 1 vs 3 (p=.043) 2 vs 3 (p=.045) 3 vs 4 (p=.022) 3 vs 5 (p=.015) |
| Receipt of endocrine therapy | 168 (62) | 112 (63) | 20 (80) | 10 (48) | 6 (60) | 20 (56) | .20 | |
| Psychosocial | ||||||||
| Childhood maltreatment | .42 | |||||||
| None | 163 (60) | 109 (61) | 17 (68) | 13 (62) | 6 (60) | 18 (50) | ||
| Non-sexual | 75 (28) | 53 (30) | 4 (16) | 6 (29) | 2 (20) | 10 (28) | ||
| Sexual | 32 (12) | 16 (9) | 4 (16) | 2 (10) | 2 (20) | 8 (22) | ||
| History of major depressive disorder | 60 (23) | 33 (19) | 6 (24) | 5 (24) | 0 (0) | 16 (44) | .01 | 1 vs 5 (p=.002) 4 vs 5 (p=.009) |
| CES-D, baseline: mean (SD) | 12.7 (10.4) | 10.0 (8.0) | 8.4 (7.9) | 19.1 (13.5) | 19.6 (11.2) | 23.2 (11.2) | <.0001 | 1 vs 3 (p<.0001) 1 vs 4 (p=.0004) 1 vs 5 (p<.0001) 2 vs 3 (p=.002) 2 vs 4 (p=.002) 2 vs 5 (p<.0001) |
| PSQI, baseline: mean (SD) | 7.4 (4.0) | 6.5 (3.6) | 6.3 (2.9) | 8.3 (4.0) | 9.9 (3.4) | 11.5 (3.7) | <.0001 | 1 vs 3 (p=.037) 1 vs 4 (p=.004) 1 vs 5 (p<.0001) 2 vs 4 (p=.004) 2 vs 5 (p<.0001) 3 vs 5 (p=.003) |
| Clinical sleep disturbance (PSQI>5) | 166 (61) | 97 (55) | 13 (52) | 13 (62) | 8 (80) | 35 (97) | <.0001 | 1 vs 5 (p<.0001) 2 vs 5 (p<.0001) 3 vs 5 (p=.001) |
| IES, baseline: mean (SD) | 1.7 (1.3) | 1.5 (1.2) | 1.6 (1.3) | 2.1 (1.3) | 2.6 (1.4) | 2.3 (1.3) | .002 | 1 vs 4 (p=.011) 1 vs 5 (p=.001) 2 vs 5 (p=.048) |
Omnibus p-values are from Fisher exact tests (categorical variables) and analysis of variance (continuous variables). P-values for pairwise comparisons of latent classes are from Fisher exact tests (categorical variables) and t-tests (continuous variables). For the Godin, the Kruskal-Wallis rank test was used for omnibus and pairwise tests. CES-D, Center for Epidemiologic Studies Depression Scale; IES, impact of Events scale; PSQI, Pittsburgh Sleep Quality Index.