Table 3.
Subgroup Analyses of Risk of Primary Brain Malignancy, According to Age and Sex Group
| Height | Total, n | Events, n | Person- years | Incidence Ratea | Unadjusted HR (95% CI) | Adjusted HRb (95% CI) | |
|---|---|---|---|---|---|---|---|
| Age < 65 | |||||||
| Quartile 1 | 1 546 938 | 724 | 11 334 204 | 6.39 | 1 (Reference) | 1 (Reference) | |
| Quartile 2 | 1 475 944 | 746 | 10 818 625 | 6.90 | 1.08 (0.98–1.20) | 1.05 (0.95–1.17) | |
| Quartile 3 | 1 511 233 | 753 | 11 079 774 | 6.80 | 1.06 (0.96–1.18) | 1.11 (1.00–1.23) | |
| Quartile 4 | 1 511 503 | 854 | 11 077 724 | 7.71 | 1.21 (1.09–1.33) | 1.22 (1.11–1.35) | |
| Age ≥ 65 | Quartile 1 | 204 068 | 317 | 1 432 709 | 22.13 | 1 (Reference) | 1 (Reference) |
| Quartile 2 | 218 526 | 391 | 1 547 838 | 25.26 | 1.14 (0.98-0.32) | 1.16 (1.00–1.34) | |
| Quartile 3 | 185 207 | 352 | 1 309 908 | 26.87 | 1.21 (1.04–1.41) | 1.21 (1.04–1.41) | |
| Quartile 4 | 180 325 | 334 | 1 277 200 | 26.15 | 1.18 (1.01–1.38) | 1.19 (1.07–1.38) | |
| Male | |||||||
| Quartile 1 | 1 013 864 | 591 | 7 359 831 | 8.03 | 1 (Reference) | 1 (Reference) | |
| Quartile 2 | 989 953 | 659 | 7 196 010 | 9.16 | 1.14 (1.02–1.27) | 1.10 (0.99–1.23) | |
| Quartile 3 | 925 692 | 619 | 6 734 174 | 9.19 | 1.15 (1.02–1.28) | 1.19 (1.07–1.34) | |
| Quartile 4 | 996 110 | 684 | 7 251 240 | 9.43 | 1.18 (1.05–1.31) | 1.21 (1.09–1.35) | |
| Female | |||||||
| Quartile 1 | 737 142 | 450 | 5 407 082 | 8.32 | 1 (Reference) | 1 (Reference) | |
| Quartile 2 | 704 517 | 478 | 5 170 453 | 9.25 | 1.11 (0.98–1.26) | 1.07 (0.94–1.21) | |
| Quartile 3 | 770 748 | 486 | 5 655 509 | 8.59 | 1.03 (0.91–1.17) | 1.06 (0.93–1.21) | |
| Quartile 4 | 695 718 | 504 | 5 103 684 | 9.87 | 1.19 (1.05–1.35) | 1.22 (1.08–1.39) |
CI, confidence interval; HR, hazard ratio.
aPer 100 000 person-years.
bAdjusted for sex, age, body mass index, smoking status, alcohol consumption, exercise level, income level, and the presence of diabetes mellitus.