Table 1.
Model-adjusted means (and standard error of the mean) of clinical pathology parameters reported by a laboratory-based assay in calves inoculated with BoHV-1 on day 0 and Mannheimia haemolytica on day 6, by study day
| Study day | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 4 | 6 | 6.5 | 7 | 7.5 | 9 | 11 | 13 | P 3 | ||
| Parameter, unit1 | Int2 | Model-adjusted mean (SEM) | |||||||||||
| Leuk 109/L | 5.0–10.0 | 11.9 a | 11.9 a | 10.5 bd | 10.2 bcd | 9.4de | 9.1de | 11.4 ab | 9.1df | 9.2abdf | 6.7cef | 6.2abdf | <0.01 |
| (1.03) | (1.04) | (1.04) | (1.04) | (1.05) | (1.06) | (1.06) | (1.06) | (1.08) | (1.14) | (1.26) | |||
| Lymp 109/L | 2.5–7.5 | 5.5a | 4.7bc | 4.6ab | 4.8ac | 5.4ab | 2.7d | 3.5f | 3.1df | 2.6df | 2.5df | 2.9abdf | <0.01 |
| (1.04) | (1.05) | (1.06) | (1.05) | (1.05) | (1.07) | (1.06) | (1.08) | (1.12) | (1.12) | (1.24) | |||
| Seg 109/L | 1.0–5.0 | 4.9ace | 5.2 ae | 4.7ace | 4.0ac | 2.7b | 4.1acd | 5.6 e | 4.1abd | 3.1bda | 2.0bc | 0.8 abe | <0.01 |
| (1.07) | (1.07) | (1.06) | (1.08) | (1.08) | (1.09) | (1.08) | (1.12) | (1.21) | (1.32) | (2.04) | |||
| Neut/lymp | No.of ref. | 0.9ae | 1.1ace | 1.0ae | 0.8 ae | 0.5b | 1.7cd | 1.8d | 1.4ade | 1.6de | 1.1abde | 0.5ab | <0.01 |
| (1.08) | (1.10) | (1.08) | (1.08) | (1.09) | (1.11) | (1.10) | (1.17) | (1.24) | (1.34) | (1.43) | |||
| Mono 109/L | 0.0–0.8 | 1.1 abdg | 1.3 de | 0.8cgh | 1.0 abdh | 0.9 abdh | 1.3 ebi | 1.1 abdh | 0.8ac | 0.8abhi | 0.3f | 0.6abfh | <0.01 |
| (1.09) | (1.09) | (1.08) | (1.09) | (1.09) | (1.11) | (1.11) | (1.09) | (1.14) | (1.21) | (1.26) | |||
| Hct spun3 | 0.26–0.42 | 0.35ai | 0.35ai | 0.34adi | 0.33beh | 0.32cdfg | 0.32cgh | 0.34aef | 0.34aef | 0.33efgi | 0.36ae | 0.38a | <0.01 |
| (0.006) | (0.006) | (0.005) | (0.006) | (0.006) | (0.006) | (0.007) | (0.012) | (0.012) | (0.012) | (0.013) | |||
| Hct calc3 | 0.24–0.46 | 0.32abc | 0.32ac | 0.31b | 0.29de | 0.29de | 0.28e | 0.30abd | 0.31abd | 0.31abde | 0.33abcd | 0.36c | <0.01 |
| (0.006) | (0.005) | (0.005) | (0.005) | (0.005) | (0.005) | (0.006) | (0.006) | (0.012) | (0.013) | (0.014) | |||
| Hemo, g/L | 80–150 | 125ac | 123acd | 118be | 116be | 116bde | 113bf | 119ae | 121aeg | 121aefg | 128aeg | 133cg | <0.01 |
| (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (4.0) | (5.0) | (4.0) | |||
| C.hemo, g/L | No. of ref. | 124ae | 122ae | 118bf | 114cdg | 114cf | 110d | 116afg | 119afg | 119adfg | 127aefg | 136e | <0.01 |
| (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (2.0) | (4.0) | (5.0) | (4.0) | |||
| Fibri, g/L | 3.0–7.0 | 4.2d | 4.6cd | 4.4d | 4.5d | 5.5cb | 5.6cb | 6.1b | 5.8bc | 7.6 a | 8.1 a | 8.7 a | <0.01 |
| (0.26) | (0.26) | (0.26) | (0.26) | (0.26) | (0.28) | (0.28) | (0.30) | (0.30) | (0.37) | (0.39) | |||
| P. prot, g/L | 70–90 | 76a | 74bcd | 75ab | 74bde | 72cf | 70ghi | 69 gi | 69 hi | 71ceg | 74acej | 76adf | <0.01 |
| (1.0) | (1.0) | (1.0) | (1.0) | (1.0) | (1.0) | (1.0) | (1.0) | (1.0) | (1.0) | (1.0) |
1Param = Parameters, Leuk = Leukocyte, Lymp = Lymphocyte, Seg = Segmented neutrophils, Neut = Neutrophils, Mono = Monocytes, Hct = Hematocrit, Hct calc = Hematocrit calculated, Hemo = Hemoglobin, C.hemo = Cellular hemoglobin, Fibri = Fibrinogen, P. prot = Plasma protein.
2Reference intervals, as provided by the Kansas State Veterinary Diagnostic Laboratory.
3Statistical difference among study days.
3Proportion of 1.
Different superscript letters within a row indicate statistically significant differences (P < 0.05). Values in bold indicate concentrations outside of the reference intervals. Calves were randomly assigned to be euthanized on days 6 to 13.