Table 4.

Model-adjusted means (× 10⁹/L) and standard error of the mean (SEM) for the 3 models evaluating the associations between (1) leukocytes, (2) neutrophils, and (3) lymphocytes reported by a point-of-care leukocyte differential (PCLD) and a laboratory-based leukocyte differential (LLD; outcome) assays while accounting for study day and an interaction between its respective cell count and study day

	LLD-leukocytes				LLD-neutrophils				LLD-lymphocytes
	Mean	SEM	P 1		Mean	SEM	P 1		Mean	SEM	P 1
PCLD-Leuk2	1.1	1.0	<0.01	PCLD-Neut2	1.2	1.0	<0.01	PCDL-Lymph2	1.1	1.0	<0.01
Study day			<0.01	Study day			<0.01	Study day			<0.01
0	Ref	Ref		0	Ref	Ref		0	Ref	Ref
1	1.0	1.10		1	1.5	1.18		1	0.8	1.19
2	0.9	1.14		2	1.9	1.17		2	0.6	1.18
4	0.9	1.12		4	1.0	1.20		4	0.6	1.20
6	0.9	1.11		6	0.9	1.28		6	0.8	1.19
6.5	1.0	1.13		6.5	1.3	1.21		6.5	0.4	1.28
7	1.3	1.11		7	2.0	1.24		7	0.7	1.22
7.5	0.9	1.11		7.5	1.4	1.23		7.5	0.9	1.31
9	0.8	1.10		9	0.7	1.48		9	0.4	1.32
11	0.6	1.12		11	0.5	1.51		11	0.4	1.32
13	0.4	1.18		13	0.0	2.89		13	0.3	1.39
PCLD*day			<0.01	PCLD*day			<0.01	PCLD*day			0.04
Leuk*0	Ref	Ref		Neut*0	Ref	Ref		Lymp*0	Ref	Ref
Leuk*1	1.0	1.01		Neut*1	0.9	1.01		Lymp*1	1.0	1.01
Leuk*2	1.0	1.01		Neut*2	0.9	1.00		Lymp*2	1.1	1.01
Leuk*4	1.0	1.02		Neut*4	1.0	1.01		Lymp*4	1.1	1.00
Leuk*6	1.0	1.02		Neut*6	1.0	1.00		Lymp*6	1.1	1.02
Leuk*6.5	1.0	1.01		Neut*6.5	1.0	1.04		Lymp*6.5	1.1	1.03
Leuk*7	1.0	1.04		Neut*7	0.9	1.03		Lymp*7	1.0	1.02
Leuk*7.5	1.0	1.03		Neut*7.5	0.9	1.03		Lymp*7.5	1.0	1.10
Leuk*9	1.0	1.04		Neut*9	1.0	1.12		Lymp*9	1.1	1.12
Leuk*11	1.0	1.00		Neut*11	1.0	1.12		Lymp*11	1.1	1.08
Leuk*13	1.1	1.00		Neut*13	2.3	1.38		Lymp*13	1.2	1.13

¹Statistical significance of a variable.

²Continuous fixed effects included in the model: Leuk = Leukocytes × 10⁹/L, Neut = Neutrophils × 10⁹/L, Lymp = lymphocytes × 10⁹/L.

Ref = reference category. Calves were inoculated with BoHV-1 on day 0 and Mannheimia haemolytica on day 6. Calves were randomly assigned to be euthanized on days 6 to 13.