TABLE 5.

Prevalence of Pancreatic Cancer in Melanoma-prone Families for 10 Pathogenic CDKN2A Variants

No. Families	Variant*	No. Families With a Member Affected With PDAC
21	p.A76fs	>60%
19	p.M53I	<11%
16	p.G101W	35% to 50%
11	p.R112_L113insR	>60%
11	c.−34G>T	15% to 25%
11	c.IVIS2–105A>G	<11%
9	p.R24P	15% to 25%
7	p.V126D	35% to 50%
6	p.L32P	35% to 50%
6	c.32_33ins9–32	<11%

^*Variant position given in reference to NP_000068.1 for protein change (p.) and NM_000077.4 for transcript change (c.). PDAC – pancreatic adenocarcinoma.