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Molecular formulas, half-lives and dosing schedules for BCR-ABL1 TKIs.
| TKI | Structural Formula | Half Life | Recommended Starting Dose |
|---|---|---|---|
| Imatinib |
|
18 hours | 400 mg daily |
| Dasatinib |
|
3–5 hours | 100 mg once daily |
| Nilotinib |
|
17 hours | 300 mg twice daily |
| Ponatinib |
|
12–66 hours | 45 mg once daily |
| Bosutinib |
|
22 hours (oral) | 400 mg once daily |
| Asciminib |
|
8 hours | 40 mg BID (estimated) |
