Table 1.
Identification of proteomic variants of Brazilian SARS-CoV-2 isolates. The variants were represented among each open reading frame (ORFs).
| Genotype | Accession | Isolates | Genes | Mutation |
|---|---|---|---|---|
| G1 | MT126808 | BRA/SP02/2020 | NSP6 | L37F |
| ORF3a | G251V | |||
| G2 | MT350282 | BRA/SP02cc/2020 | NSP2 | T528I |
| NSP6 | L37F | |||
| Spike | N74K | |||
| ORF3a | G251V | |||
| G3 | MT710714 | BRA/RJ01/2020 | NSP2 | T85I |
| NSP7 | S25L | |||
| RdRp | P323L | |||
| Exonuclease | A320V | |||
| Spike | D614G | |||
| ORF3a | Q57H | |||
| G4 | MT738173 | BRA/HIAE-SP04/2020 | NSP7 | L71F |
| RdRp | P323L | |||
| Spike | D614G, V1176F | |||
| Nucleocapsid | R203K, G204R | |||
| G5 | MT738101 | BRA/HIAE-SP03/2020 | NSP6 | T17I |
| RdRp | P323L | |||
| Spike | D614G | |||
| ORF3a | S171L | |||
| ORF6 | I33T | |||
| Nucleocapsid | R203K, G204R, I292T | |||
| G6 | MT807936 | BRA/LRV-SARS.CoV-2.1/2020 | RdRp | P323L |
| Spike | D614G | |||
| ORF6 | I33T | |||
| Nucleocapsid | R203K, G204R, I292T | |||
| G7 | MT827202 | BRA/RJ-DCVN1/2020 | NSP2 | T85I |
| NSP7 | S25L | |||
| RdRp | P323L | |||
| Exonuclease | A320V | |||
| Spike | D614G | |||
| ORF3a | Q57H | |||
| G8 | MT835026 | BRA/RJ-DCVN2/2020 | RdRp | P323L |
| Spike | D614G | |||
| G9 | MT835383 | BRA/RJ-DCVN5/2020 | RdRp | P323L |
| Spike | D614G | |||
| Envelope | V5A | |||
| G10 | MW593153 | BRA/MASP1C844R1/2020 | RdRp | P323L |
| Spike | D614G | |||
| ORF6 | I33T | |||
| Nucleocapsid | R203K, G204R, I292T, P383L | |||
| G11 | MW592707 | BRA/MASP2C844R2/2020 | NSP2 | V577F |
| NSP7 | L71F | |||
| RdRp | P323L | |||
| Ribose | R216N | |||
| Spike | D614G, V1176F | |||
| Nucleocapsid | R203K, G204R | |||
| G12 | MZ169916 | BRA/1462/2021 | NSP2 | G88E |
| 3CLPro | L205V | |||
| NSP6 | L37F | |||
| NSP7 | L71F | |||
| RdRp | P323L | |||
| Exonuclease | T16A, Y235N | |||
| EndRNAse | K110R | |||
| Spike | E484K, D614G, V1176F | |||
| Nucleocapsid | A119S, S202T, R203K, G204R, M234I | |||
| G13 | MZ169912 | BRA/1431/2021 | NSP2 | G88E |
| 3CLPro | L205V | |||
| NSP7 | L71F | |||
| RdRp | P323L | |||
| Exonuclease | T16A | |||
| EndRNAse | K110R | |||
| Spike | E484K, D614G, V1176F | |||
| Nucleocapsid | A119S, S202T, R203K, G204R, M234I | |||
| G14 | MZ264787 | BRA/CD1739-P4/2020 | PLPro | S375L, K982Q, S1740F |
| 3CLPro | P96H | |||
| NSP6 | S106T, G107S, F108L | |||
| RdRp | P323L | |||
| Helicase | E341D | |||
| Spike | L18F, T20N, P26S, D138Y, R190S, E484K, N501Y, D614G, H655Y, T1027I, V1176F | |||
| ORF3a | S253P | |||
| ORF8 | E92K | |||
| Nucleocapsid | P80R, R203K, G204R | |||
| G15 | MZ169911 | BRA/1236/2021 | NSP2 | S138L |
| PLPro | S375L, K982Q | |||
| NSP4 | S184N | |||
| NSP6 | F108L | |||
| RdRp | P323L | |||
| Helicase | E341D | |||
| Exonuclease | N256S | |||
| Spike | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F | |||
| ORF3a | S253P | |||
| Membrane | A2V | |||
| ORF8 | E92K | |||
| Nucleocapsid | P80R, R203K, G204R | |||
| G16 | MZ169910 | BRA/1061/2021 | NSP2 | K534N |
| PLPro | S375L, K982Q | |||
| RdRp | P323L | |||
| Helicase | E341D | |||
| Spike | L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F | |||
| ORF3a | S253P | |||
| ORF8 | E92K | |||
| Nucleocapsid | P80R, R203K, G204R |