Fig. 2.

The Proposed Immunomodulatory Effects of Macrolide Antibiotics on Neutrophil Function. Macrolides antibiotics (MA) might affect various neutrophil functions. They have been reported to enhance apoptosis and reduce chemotaxis. Conflicting findings regarding the effect of macrolides on neutrophil degranulation [[70], [71], [72], [73], [74]], NETosis [[74], [75], [76], [77]] and the oxidative burst [74,78] highlight the lack of understanding of the impact these drugs have on neutrophil processes. Question marks indicate proposed effects of macrolides that require further experimental support.