Figure 3.

Endoplasmic reticulum stress effector XBP1 was found to be a key transcriptional regulator in ectopic ossified tissues. (a) Regulatory modules were identified based on the regulon connection specificity index matrix, and the core transcription factors, binding motifs, and corresponding cell types were extracted. (b) The activity of each module in different cells is represented by tSNE plots. (c) Corresponding cell types of different modules. (d) The Venn diagram reveals that Xbp1 is a common key transcription factor for heterotopic ossification bulk-RNA-seq and scRNA-seq analyses.