. 2020 Dec 31;73(9):e2789–e2798. doi: 10.1093/cid/ciaa1901

Table 5.

Adverse Outcomes of Patients Treated With Pulse Corticosteroid Taper Therapy (PCT) for Cryptococcal Post-infectious Inflammatory Response Syndrome (PIIRS)

Complications	N = 15 (%)
Infections	0
Osteopenia requiring bisphosphonates	2(13)
Fractures	0
Posterior subcapsular cataracts	4 (27)
Refractory adrenal insufficiency	0
Aseptic necrosis	0
Ocular hypertension	2 (13)
Steroid-induced hyperglycemia	3^a (20)
Weight gain > kg 6 months post-pulse	7 (47)
Neuropsychiatric symptoms	1^b(7)

^a Patient 1 had an underlying history of diabetes mellitus; in the other 2 patients, it subsided with no requirement for long-term insulin use.

^b Resolved.