. 2020 Jul 8;73(9):e3340–e3346. doi: 10.1093/cid/ciaa949

Table 1.

Diagnostic Performance of HCV-RNA RT-PCR in Perinatally Exposed Infants Age 2–6 Months

	Point Estimate	95% CI
Sensitivity, (%)^a	100	87.5–100
Specificity, (%)^a	100	98.3–100
Positive likelihood ratio^b	∞	78.0–∞
Negative likelihood ratio^b	0	0–.103
Assume 5.8% prevalence^c
Positive-predictive value, (%)^d	100	82.8–100
Negative-predictive value, (%)^d	100	99.4–100
Assume 3.6% prevalence^e
Positive-predictive value, (%)^d	100	74.5–100
Negative-predictive value, (%)^d	100	99.6–100

Data are presented as percentages unless otherwise indicated.

Abbreviations: CI, confidence interval; HCV, hepatitis C virus; RT-PCR, reverse transcription–polymerase chain reaction.

^aCIs determined by Wilson-Brown method.

^bCIs determined by bootstrapping method of Marill et al [29].

^cRisk of perinatal HCV transmission from viremic mothers (Benova et al [8]).

^dPredictive values and CIs derived by application of likelihood ratios to the pre-test odds associated with the given prevalence.

^eEstimated risk of perinatal HCV transmission in this study cohort of infants tested due to history of maternal HCV infection (without requirement for documented maternal viremia during pregnancy).