Table 2.

Variables Versus Severity and Outcomes (Unadjusted)

Variable	IDSA Severity		30-Day Mortality		DRCsa
	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Age	1.00 [0.99, 1.01]	.745	1.03 [1.01, 1.05]	.009**	1.03 [1.01, 1.06]	.013*
White race	1.33 [0.71, 2.60]	.384	0.82 [0.35, 2.22]	.658	0.40 [0.65, 0.26]	.394
Female sex	1.05 [0.69, 1.58]	.823	1.27 [0.67, 2.44]	.459	1.05 [0.69, 1.58]	.823
Albumin, g/dL	0.58 [0.41, 0.80]	.001***	0.14 [0.07, 0.26]	<.001***	0.20 [0.10, 0.37]	<.001***
Total bilirubin, mg/dL	1.12 [1.02, 1.26]	.028*	1.25 [1.13, 1.40]	<.001***	1.28 [1.16, 1.44]	<.001***
PPI	1.84 [1.07, 3.21]	.030*	2.38 [1.02, 6.52]	.063	5.01 [1.42, 31.8	.032*
Prior high-risk antibiotic	1.03 [0.39, 2.53]	.957	2.71 [0.85, 7.32]	.063	1.43 [0.22, 5.36]	.642
Concurrent high-risk antibiotic	1.42 [0.73, 2.71]	.295	0.79 [0.23, 2.13]	.677	1.92 [0.61, 5.17]	.223
IBD	0.75 [0.42, 1.30]	.318	0.12 [0.01, 0.55]	.036*	0.58 [0.14, 1.69]	.381
Ribotypes
027	1.57 [0.69, 3.51]	.275	0.26 [0.01, 1.59]	.238	0.40	.719
014–020	1.21 [0.76, 2.29]	.320	3.33 [1.59, 6.80]	.001	3.17 [1.28, 7.57]	.010*
106	0.72[0.33, 1.48]	.387	0.51 [0.08, 1.75]	.367	0.84 [0.13, 2.98]	.818
002	1.63 [0.78, 3.40]	.190	0.28 [0.02, 1.32]	.208	0.39 [0.01, 2.50]	.498
Detectable stool toxin by EIA	1.85 [1.18, 2.89]	.007**	1.09 [0.53, 2.12]	.805	0.74 [0.29, 1.69]	.501
Quantitative toxin >6.4 ng/mLb	2.11 [1.22, 3.80]	.009**	1.44 [0.52, 3.93]	.430	0.83 [0.33, 2.36]	.704

Significance levels: *P < .05, **P < .01, ***P < .001.

Abbreviations: CDI, Clostridioides difficile infection; DRC, disease-related complication; EIA, enzyme immunoassay; IBD, inflammatory bowel disease; IDSA, Infectious Diseases Society of America; OR, odds ratio; PPI, proton pump inhibitors.

^aDefined as occurrence of any of the following outcomes attributed to CDI within 30 days of diagnosis: admission to an intensive care unit, colectomy, or death.

^bMeasured by a custom cell cytotoxicity assay.