. 2021 Jun 28;23(11):1821–1834. doi: 10.1093/neuonc/noab150

Table 2.

Molecular Targets

Drug Class	Molecular Target/Biomarker
AKT inhibitor	AKT1 (pGlu17Lys) mutation^24,25
Hedgehog inhibitor	SMO (pTrp535Leu) mutation^24,25
FAK inhibitor	NF2 (merlin) loss^43,44
Immune checkpoint inhibitor	PD-L1, PD-L2, B7-H3, and CTLA-4^45–47
VEGF or VEGFR inhibitor	VEGF or VEGFR2^48–50
PI3K inhibitor	PI3K²⁹
mTOR inhibitor	mTOR^51,52
Somatostatin analog	Somatostatin receptors⁵¹
Gemcitabine	Cytidin⁵³

Abbreviation: AKT, gene coding for protein kinase B; FAK, focal adhesion kinase; mTOR, mammalian target of rapamycin; PI3K, phospho-inositol-3-kinase; VEGF, vascular endothelial growth factor.