Fig. 1.

Workflow and clinical information for single-cell sequencing analysis of PitNETs. (A) The workflow for the scRNA-seq and single-cell multi-omics sequencing analysis of PitNETs. (B) Clinical details of the patients, who are ordered by tumor type. Somato, somatotroph tumors; Lacto, lactotroph tumors; Thyro, thyrotroph tumors; PIT-1+Pluri, plurihormonal PIT-1-positive tumors; Cortico, corticotroph tumors; Gonado, gonadotroph tumors; PAwUIC, pituitary adenoma with unusual immunohistochemical combinations. * indicates the patient had 2 surgical samples. (C) Heatmap showing clinical immunohistochemical results and scRNA-seq results with the scaled average expression of hormone genes and transcription factors (TFs). Samples are arranged in the same order as Figure 1B. Abbreviations: PitNETs, pituitary neuroendocrine tumors; scRNA-seq, single-cell RNA sequencing.