Fig. 5.

Single-cell multi-omics sequencing of PitNETs. (A) CNV profiles inferred from scRNA-seq in individual cells from each patient, verified by bulk WGS in selected cases. (B–D) CNV profiles detected by MALBAC at a 1-Mb resolution in 4 single tumor cells from P20 (B), P21 (C), and P18 (D). Cells are in cluster C2 in Supplementary Figure S5C–E. Abbreviations: CNV, copy number variations; MALBAC, multiple annealing and looping-based amplification cycle; PitNETs, pituitary neuroendocrine tumors; scRNA-seq, single-cell RNA sequencing; WGS, whole-genome sequencing.