Fig. 3.

Overall survival measured from the time of histologically proven high-grade transformation is shown, (A) stratifying by grade and molecular subtype, (B) hypermutation status, and (C) treatment with radiotherapy prior to transformation. In panel D, we show a bivariate model of survival after transformation, accounting for hypermutation status and receipt of radiotherapy. (D) Multivariate analysis of grade III tumors showing both hypermutation and prior radiation remain significant predictors of survival. Abbreviations: Astro, IDH-mutant astrocytoma; IDH, isocitrate dehydrogenase; Oligo, IDH-mutant 1p/19q co-deleted oligodendroglioma.