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Kaplan-Meier plot of (A) progression-free survival (PFS) as assessed by the investigators and (B) overall survival (OS) in symptomatic patients. Symbols indicate censored observations. Median PFS was 1.2 months (95% CI: 0.7-1.3) for intracranial disease, 2.2 months (95% CI: 0.8-not reached) for extracranial disease, and 1.2 months (95% CI: 0.8-not reached) for global disease. Median OS was 8.7 months (95% CI: 8.8-not reached).
