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. 2021 Nov 3;42(1):111–128. doi: 10.1016/j.cll.2021.10.008

Table 2.

Proposed correlates of protection

Study Design Authors Natural Infection or Postimmunization Endpoint Correlates of Protection Identified
Passive immunity Weinreich et al,47 2021
Chen et al,48 2021		 Passive antibody transfer SARS-CoV-2 viral load nAb, no specific threshold determined
Animal model McMahan et al,50 2021 Natural infection SARS-CoV-2 PCR detection in BAL 50 for pseudovirus nAb titers; 100 for RBD ELISA titers; 400 for S ELISA titers
Animal model Corbett et al,52 2020 Postimmunization SARS-CoV-2 PCR detection in BAL nAb, no specific threshold determined
Animal model Mercado et al,51 2020 Postimmunization SARS-CoV-2 PCR detection in BAL nAb 100–250
Cohort study Addetia et al,58 2020 Natural infection SARS-CoV-2 PCR (nasopharyngeal) and clinical symptoms nAb were protective in 3 crew members with levels of 1:174, 1:161, and 1:3082