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Mechanism by which MYB drives oncogene activation in inv(3)/t(3;3) AML. A CRISPR/Cas9 scan of the GATA2 translocated enhancer pinpointed a single regulatory element containing a MYB-binding motif critical for EVI1 expression (top). MYB preferentially occupies the translocated enhancer driving EVI1 expression. Inference with MYB downregulates EVI1 but not GATA2 levels (bottom).
