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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Cancer Res. 2021 Jul 21;81(21):5425–5437. doi: 10.1158/0008-5472.CAN-20-1723

Figure 7. Hh/GLI signaling impacts metabolic reliance on glycolysis with reciprocal decrease in OXPHOS.

Figure 7.

BMDMs skewed to macrophages were used for all panels. A. Schematic for Seahorse mitochondrial stress test. Seahorse XFe24 extracellular flux analyzer was used to calculate: B. Oxygen consumption rate (OCR), C. Proton leak, non-mitochondrial respiration, reserve capacity, D. Basal and maximal respiration, and E. Basal extracellular acidification rate (ECAR). F. Macrophages (BMDMs skewed to M2 +/− Hhi) stained with JC-1.