Table 1.
Demographic and physiologic characteristics for all participants and by tertiles of serum IL-6
| Characteristic | All Participants (n=96) |
IL-6 | P value | ||
|---|---|---|---|---|---|
| Low (n=32) | Intermediate (n=32) |
High (n=32) | |||
| Demographic | |||||
| Age a (yr) | 50.4 (±12.8) | 46.6 (±13.8) | 50.8 (±12.7) | 53.7 (±11.2) | 0.08 |
| Woman (%) | 31.25 | 28.1 | 28.1 | 37.5 | 0.65 |
| African American (%) | 62.5 | 62.5 | 62.5 | 62.5 | 0.67 |
| Baseline | |||||
| DM (%) | 52.7 | 50 | 40.6 | 68.9 | 0.08 |
| CVD (%) | 25 | 15.6 | 25 | 34.4 | 0.22 |
| Ever smoker (%) | 52.7 | 53.1 | 59.4 | 44.8 | 0.52 |
| BMI a (kg/m2) | 29.4 (±5.9) | 27.7 (±4.9) | 31.1 (±6.6) | 29.3 (±5.6) | 0.07 |
| SBP a (mmHg) | 136.7 (±20.6) | 139.9 (±19.7) | 135.8 (±22.6) | 134.4 (±19.7) | 0.55 |
| DBP a (mmHg) | 77.8 (±12.1) | 78.3 (±11.4) | 80.0 (±12.5) | 75.1 (±12.2) | 0.25 |
| Laboratory assessment | |||||
| Total Cholesterol a (mg/dl) | 169.3 (37.6) | 179.9 (39.6) | 170 (31.5) | 157.8 (39.1) | 0.06 |
| PTH a (pg/ml) | 251.1 (208.3) | 240.9 (213.0) | 298.2 (272.1) | 214.1 (98.3) | 0.26 |
| Vitamin D a | 25.7 (15.1) | 27.6 (12.9) | 25.6 (16.5) | 23.9 (15.8) | 0.62 |
| Phosphate a (mg/dl) | 4.5 (1.3) | 4.7 (1.4) | 4.6 (1.4) | 4.3 (1.2) | 0.43 |
| Calcium a (mg/dl) | 8.8 (1.1) | 8.9 (1.1) | 8.9 (1.0) | 8.5 (1.1) | 0.15 |
| Albumin a (g/dl) | 3.5 (0.6) | 3.6 (0.6) | 3.6 (0.6) | 3.2 (0.5) | 0.02 |
| Median hsCRP (mg/L) (IQR) | 6.4 (2.7-13.9) | 3.5 (0.6-4.8) | 6.6 (2.7-12.4) | 13.8 (8.1-30.3) | 0.002 |
| Median TNF-α (pg/ml) (IQR) | 4.1 (3.0-5.4) | 3.5 (2.9-4.5) | 3.9 (2.9-4.9) | 4.9 (3.8-6.7) | 0.11 |
| Median FGF-23 (RU/ml) (IQR) | 1195.6 (509.7-2216.9) | 1527.7 (629.0-3565.5) | 810.0 (437.1-1624.9) | 1205.5 (723.9-2240.6) | 0.26 |
| Median Baseline CAC score (IQR) | 43.4 (0-292.4) | 0.3 (0-212.2) | 29.6 (0-182.9) | 133.3 (10.4-466.2) | 0.02 |
| Medications | |||||
| Beta blocker (%) | 65.9 | 60 | 71.9 | 65.5 | 0.61 |
| ACE/ARB (%) | 48.4 | 56.7 | 50.0 | 37.9 | 0.35 |
| Diuretic (%) | 39.6 | 40 | 37.5 | 41.4 | 0.95 |
| CCB (%) | 60.4 | 66.7 | 46.9 | 68.9 | 0.15 |
| Nitrates (%) | 14.3 | 13.3 | 3.1 | 27.6 | 0.02 |
| Alpha Blocker (%) | 25.3 | 16.7 | 28.1 | 31.0 | 0.40 |
| Statins (%) | 35.4 | 37.5 | 37.5 | 31.3 | 0.83 |
| Aspirin (%) | 29.7 | 16.7 | 37.5 | 34.5 | 0.16 |
Note: Due to missing values, total may not always equal 96.
a
Mean (SD)