Table 1.

Eligibility and Ineligibility Criteria

Eligibility Criteria
Individual who is 18 years or older
Individual who has signed informed consent
Individual who has been informed about:
A first or second-degree relative with a diagnosis of pancreatic ductal adenocarcinoma (PDAC) and a germline pathogenic variant in APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11 or TP53
OR
An unaffected first or second-degree relative with a germline pathogenic variant in one of these genes who has a first or second-degree relative with PDAC
The germline pathogenic variant and history of PDAC must both be on the maternal or paternal side of the family
Individual with a valid mailing address
Ineligibility Criteria
Individual with a known cancer pathogenic variant
Individual who has received prior genetic counseling for cancer risk
Individual who has received a bone marrow transplant, who has had a blood transfusion within the last 7 days, or who has an active malignancy (i.e. leukemia or lymphoma)*
Individual who is unable to sign the informed consent because of mental incompetency or psychiatric illness
Individual who is unwilling to complete baseline and follow-up questionnaires
Individual who has a life expectancy of less than 1 year
Individual with only an APC I1307K pathogenic variant within their family
Individual with only a PMS2 exons 12–15 deletion pathogenic variant within their family

^*Since the study was done in relatives of PDAC cases, we also excluded any individual who had a diagnosis of PDAC