Skip to main content
. 2021 Aug 18;27(21):6001–6011. doi: 10.1158/1078-0432.CCR-21-1819

Figure 3.

Figure 3. Correlation of steroid levels in serum and metastatic tissue before and after treatment with AA plus prednisone. A, Heatmap of steroid correlations in pretreatment serum (day 0) and metastatic tissue biopsies (Biopsy 1). The Spearman r value for each correlation is shown in the box. Correlations with P < 0.05 in black, P < 0.10 in italics, P > 0.10 in gray. B, Heatmap of Spearman correlations for steroids in serum at week 4 (wk4), week 8 (wk8), and week 12 (wk12). C, Comparison of baseline serum steroid levels stratified by serum DHEAS levels above (blue) versus below (red) the median at baseline (d0). D and E, Comparison of DHEAS levels (D) and DHEA levels (E) in serum stratified by baseline serum DHEAS levels at baseline (0 weeks); at 4, 8, and 12 weeks; and at EOS. Significant Spearmen correlations between on-treatment and baseline values at each time point is indicated below the timepoint. F, Comparison of steroid levels in pretreatment tissue biopsies (bx 1) stratified by serum DHEAS levels above (blue) vs. below (red) the median at baseline. G, Comparison of tissue (tx) DHEAS levels stratified by baseline serum DHEAS levels in pretreatment and on-treatment tissue biopsies (bx1 and bx2). P values for the indicated comparison calculated via nonparametric Mann–Whitney t tests. ABI, abiraterone; D4 ABI, D4-abiraterone; Keto ABI, 3-keto-5α-abiraterone; Preg, pregnenolone; Prog, progesterone; Test, testosterone.

Correlation of steroid levels in serum and metastatic tissue before and after treatment with AA plus prednisone. A, Heatmap of steroid correlations in pretreatment serum (day 0) and metastatic tissue biopsies (Biopsy 1). The Spearman r value for each correlation is shown in the box. Correlations with P < 0.05 in black, P < 0.10 in italics, P > 0.10 in gray. B, Heatmap of Spearman correlations for steroids in serum at week 4 (wk4), week 8 (wk8), and week 12 (wk12). C, Comparison of baseline serum steroid levels stratified by serum DHEAS levels above (blue) versus below (red) the median at baseline (d0). D and E, Comparison of DHEAS levels (D) and DHEA levels (E) in serum stratified by baseline serum DHEAS levels at baseline (0 weeks); at 4, 8, and 12 weeks; and at EOS. Significant Spearmen correlations between on-treatment and baseline values at each time point is indicated below the timepoint. F, Comparison of steroid levels in pretreatment tissue biopsies (bx 1) stratified by serum DHEAS levels above (blue) vs. below (red) the median at baseline. G, Comparison of tissue (tx) DHEAS levels stratified by baseline serum DHEAS levels in pretreatment and on-treatment tissue biopsies (bx1 and bx2). P values for the indicated comparison calculated via nonparametric Mann–Whitney t tests. ABI, abiraterone; D4 ABI, D4-abiraterone; Keto ABI, 3-keto-5α-abiraterone; Preg, pregnenolone; Prog, progesterone; Test, testosterone.