Table 1.
Patient Characteristics
| Characteristics | gATM | gBRCA2 | P |
|---|---|---|---|
| Number of patients | 45 | 45 | |
| Stage M1 at diagnosis (%) | 17 (38) | 17 (38) | |
| Age (median [IQR]) | 58 [54, 66] | 62 [55, 67] | 0.2 |
| PSA (median [IQR]) | 24 [9, 76] | 11 [6, 46] | 0.13 |
| Grade (%) | |||
| 2 | 6 (17) | 4 (11) | |
| 3 | 7 (20) | 5 (14) | |
| 4 | 5 (14) | 8 (22) | |
| 5 | 17 (49) | 20 (54) | |
| Family history of cancer meeting Prostate Cancer NCCN Guidelines for germline testing20 (%) | 25 (60) | 29 (71) | 0.4 |
| Known other primary cancers (%) | 5 (11) | 4 (9) | >0.9 |
| Pathology (%) | |||
| acinar | 24 (80) | 22 (76) | |
| ductal | 3 (10) | 3 (10) | |
| intraductal | 0 ( 0) | 1 ( 3) | |
| cribriform | 1 ( 3) | 1 ( 3) | |
| neuroendocrine | 2 ( 7) | 2 ( 7) | |
| Prostatectomy (%) | 20 (44) | 22 (50) | 0.7 |
| Radiotherapy (%) | 22 (51) | 24 (56) | 0.8 |
| Bone metastasis at the time of diagnosis (%) | 14 (31) | 15 (33) | >0.9 |
| Nodal metastasis at the time of diagnosis (%) | 13 (29) | 11 (24) | 0.8 |
| Visceral metastasis at the time of diagnosis (%) | 1 ( 2) | 3 ( 7) | 0.6 |