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. 2021 May 19;21(1):e12739. doi: 10.1111/gbb.12739

FIGURE 1.

FIGURE 1

Gross RTT‐like phenotypes are rescued with MECP2 transgene in male and female R294X mice. (A) Body weights of male R294X mice are lower than that of WT littermates at 4 weeks of age and beyond. This phenotype is rescued by MECP2 transgene in male R294X TG mice, whose body weights are not different from WT. (WT n = 6, blue; R294X n = 5, orange; TG n = 9, green; R294X TG n = 8, purple) (B) Male R294X mice exhibit progression of RTT‐like phenotypes, as reflected by an increase in phenotypic score, which is rescued by MECP2 transgene. (WT n = 6; R294X n = 5; TG n = 9; R294X TG n = 8) (C) Female R294X mouse body weights are not different from that of WT littermates. (WT n = 5; R294X n = 11; TG n = 7; R294X TG n = 9) (D) Female R294X mice exhibit progression of RTT‐like phenotypes, as reflected by an increase in phenotypic score, which is rescued by MECP2 transgene. (WT n = 5; R294X n = 11; TG n = 7; R294X TG n = 9)