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. 2021 May 19;21(1):e12739. doi: 10.1111/gbb.12739

FIGURE 2.

FIGURE 2

RTT‐specific breathing phenotypes are rescued with MECP2 transgene in male R294X mice. (A) Male R294X mice have an altered breathing pattern compared with WT littermates at 20 weeks of age, which is rescued by addition of MECP2 transgene in male R294X TG mice. (Colors as in Figure 1). (B) Basal breathing rate is elevated in male R294X mice compared with WT littermates, which is rescued by addition of MECP2 transgene. (Age: 20 weeks. WT n = 12; R294X n = 15; TG n = 16; R294X TG n = 16) (C) Breathing irregularity score, which reflects the instantaneous rate of change in total breath time, is elevated in male R294X mice compared with WT littermates. This phenotype is rescued by addition of MECP2 transgene in male R294X TG mice. (Age: 20 weeks. WT n = 12; R294X n = 15; TG n = 16; R294X TG n = 16) (D) Male R294X mice have increased apneic events compared with WT littermates, which is rescued by addition of MECP2 transgene. (Age: 20 weeks. WT n = 12; R294X n = 15; TG n = 16; R294X TG n = 16)