Table- 3.
MHC-II epitopes with its binding allele (IC50 < 500 nM).
| HTL Epitope | Position | Allele | IC50 | Antigenicity (vaxijen v2.0) | |
|---|---|---|---|---|---|
| 1. | MFVFLVLLPLVSSQC | S (1–15) | HLA-DRB1*01:01, | 5 | 0.5741 |
| HLA-DRB1*11:01, | 18 | ||||
| HLA-DPA1*03:01/DPB1*04:02, | 23 | ||||
| HLA-DRB1*04:05, | 41 | ||||
| HLA-DRB5*01:01, | 41 | ||||
| HLA-DPA1*01:03/DPB1*02:01, | 46 | ||||
| HLA-DPA1*02:01/DPB1*01:01, | 51 | ||||
| HLA-DRB1*15:01, | 96 | ||||
| HLA-DRB1*04:01, | 114 | ||||
| HLA-DRB1*07:01, | 118 | ||||
| HLA-DPA1*01/DPB1*04:01, | 132 | ||||
| HLA-DRB4*01:01, | 162 | ||||
| HLA-DRB1*12:01, | 232 | ||||
| HLA-DRB1*09:01, | 248 | ||||
| HLA-DRB1*08:02, | 421 | ||||
| HLA-DPA1*02:01/DPB1*05:01 | 422 | ||||
| 2. | RVVVLSFELLHAPAT | S (509–523) | HLA-DRB1*01:01, | 5 | 0.7485 |
| HLA-DPA1*02:01/DPB1*01:01, | 34 | ||||
| HLA-DPA1*03:01/DPB1*04:02, | 47 | ||||
| HLA-DPA1*01:03/DPB1*02:01, | 58 | ||||
| HLA-DRB1*03:01, | 111 | ||||
| HLA-DRB1*09:01, | 128 | ||||
| HLA-DRB1*11:01, | 147 | ||||
| HLA-DRB1*04:01, | 194 | ||||
| HLA-DRB5*01:01, | 199 | ||||
| HLA-DRB1*15:01, | 207 | ||||
| HLA-DPA1*01/DPB1*04:01, | 221 | ||||
| HLA-DRB4*01:01, | 311 | ||||
| HLA-DRB1*07:01, | 347 | ||||
| HLA-DRB1*04:05, | 366 | ||||
| HLA-DQA1*01:01/DQB1*05:01 | 372 | ||||
| 3. | LPIGINITRFQTLLA | S (229–243) | HLA-DPA1*01:03/DPB1*02:01, | 24 | 0.8156 |
| HLA-DRB4*01:01, | 42 | ||||
| HLA-DPA1*03:01/DPB1*04:02, | 52 | ||||
| HLA-DPA1*01/DPB1*04:01, | 75 | ||||
| HLA-DPA1*02:01/DPB1*01:01, | 125 | ||||
| HLA-DRB1*01:01, | 135 | ||||
| HLA-DRB1*15:01, | 168 | ||||
| HLA-DRB1*04:01, | 175 | ||||
| HLA-DRB1*09:01, | 208 | ||||
| HLA-DRB1*07:01, | 210 | ||||
| HLA-DRB1*08:02, | 223 | ||||
| HLA-DRB1*11:01, | 244 | ||||
| HLA-DRB1*04:05, | 300 | ||||
| HLA-DQA1*01:02/DQB1*06:02 | 471 | ||||
| 4. | AYYVGYLQPRTFLLK | S (264–278) | HLA-DRB1*01:01, | 26 | 0.4269 |
| HLA-DPA1*02:01/DPB1*01:01, | 70 | ||||
| HLA-DPA1*01:03/DPB1*02:01, | 97 | ||||
| HLA-DPA1*01/DPB1*04:01, | 133 | ||||
| HLA-DRB1*07:01, | 133 | ||||
| HLA-DRB1*04:05, | 151 | ||||
| HLA-DRB1*15:01, | 175 | ||||
| HLA-DPA1*03:01/DPB1*04:02, | 179 | ||||
| HLA-DRB5*01:01, | 202 | ||||
| HLA-DRB1*11:01, | 253 | ||||
| HLA-DRB1*04:01, | 263 | ||||
| HLA-DRB1*09:01 | 468 | ||||
| 5. | NIDGYFKIYSKHTPI | S (196–210) | HLA-DRB1*11:01, | 28 | 0.4465 |
| HLA-DRB1*01:01, | 41 | ||||
| HLA-DRB1*15:01, | 80 | ||||
| HLA-DRB1*07:01, | 93 | ||||
| HLA-DRB5*01:01, | 119 | ||||
| HLA-DRB1*04:01, | 297 | ||||
| HLA-DRB1*09:01, | 379 | ||||
| HLA-DRB1*04:05 | 486 | ||||
| 6. | RAAEIRASANLAATK | S (1014–1028) | HLA-DQA1*05:01/DQB1*03:1, | 0.5709 | |
| HLA-DRB1*01:01, | |||||
| HLA-DRB1*09:01, | |||||
| HLA-DRB1*13:02, | |||||
| HLA-DQA1*01:02/DQB1*06:02, | |||||
| HLA-DRB1*04:01, | |||||
| HLA-DRB1*08:02, | |||||
| HLA-DRB1*07:01, | |||||
| HLA-DRB1*11:01 | |||||
| 7. | SNLLLQYGSFCTQLN | S (750–764) | HLA-DRB1*15:01, | 46 | 0.8305 |
| HLA-DRB1*04:05, | 54 | ||||
| HLA-DPA1*01:03/DPB1*02:01, | 90 | ||||
| HLA-DRB1*01:01, | 96 | ||||
| HLA-DRB1*04:01, | 134 | ||||
| HLA-DPA1*02:01/DPB1*01:01, | 350 | ||||
| HLA-DPA1*01/DPB1*04:01 | 361 | ||||
| 8. | RTLSYYKLGASQRVA | M (174–187) | HLA-DRB1*01:01, | 8 | 0.5644 |
| HLA-DRB1*09:01, | 19 | ||||
| HLA-DRB1*07:01, | 23 | ||||
| HLA-DRB5*01:01, | 38 | ||||
| HLA-DQA1*05:01/DQB1*03:01, | 124 | ||||
| HLA-DRB1*04:01, | 251 | ||||
| HLA-DRB1*15:01, | 304 | ||||
| HLA-DRB1*11:01, | 309 | ||||
| HLA-DRB1*13:02, | 317 | ||||
| HLA-DRB1*04:05 | 444 | ||||
| 9. | PKEITVATSRTLSYY | M (165–179) | HLA-DRB1*07:01, | 33 | 0.7003 |
| HLA-DRB1*01:01, | 108 | ||||
| HLA-DRB1*09:01, | 160 | ||||
| HLA-DRB1*03:01, | 215 | ||||
| HLA-DRB5*01:01, | 281 | ||||
| HLA-DRB1*04:01, | 325 | ||||
| HLA-DRB1*11:01 | |||||
| 10. | FYVYSRVKNLNSSRV | E (56-70) | HLA-DRB1*01:01, | 16 | 0.6103 |
| HLA-DRB1*07:01, | 43 | ||||
| HLA-DRB1*11:01, | 58 | ||||
| HLA-DRB1*04:01, | 65 | ||||
| HLA-DRB1*04:05, | 68 | ||||
| HLA-DRB1*09:01, | 97 | ||||
| HLA-DRB1*13:02, | 134 | ||||
| HLA-DRB1*15:01, | 183 | ||||
| HLA-DRB5*01:01, | 21 | ||||
| HLA-DRB1*08:02, | 289 | ||||
| HLA-DPA1*03:01/DPB1*04:02 | 375 |