Table 3.
Descriptive Statistics for sICAM-1, HDL and FEV1 at Baseline (day 1), Day 90 and Day 180 in the Day 180 CEVal-compliant per-protocol population
| Biomarker (units) | Groupa | Nb | Day 1 | Day 90 | Day 180 |
|---|---|---|---|---|---|
| sICAM-1c (ng/mL) | A | 58–59 | 474.3 (444.4, 504.2) | 491.0 (454.9, 527.1) | 501.8 (463.6, 540.0) |
| B | 94–97 | 464.4 (437.6, 491.1) | 428.0 (409.1, 447.0) | 433.2 (410.3, 456.1) | |
| HDLd (mmol/L) | A | 58–59 | 1.39 (1.29, 1.49) | 1.39 (1.28, 1.49) | 1.37 (1.26, 1.49) |
| B | 94–97 | 1.41 (1.34, 1.48) | 1.49 (1.41, 1.57) | 1.48 (1.40, 1.56) | |
| FEV1%prede | A | 55–58 | 91.5 (88.5, 94.5) | 90.1 (87.0, 93.1) | 88.1 (85.1, 91.0) |
| B | 89–93 | 91.9 (89.7, 94.2) | 92.8 (90.5, 95.1) | 93.0 (90.8, 95.1) |
Data are means with lower and upper 95% confidence intervals in parentheses
aGroup A continue to smoke combustible cigarettes, Group B, switch to THP
bN, number of participants (for details of participant composition refer to Supplementary Table 1)
csICAM-1 soluble intercellular adhesion molecule-1
dHDL high-density lipoprotein
eFEV1%pred forced expiratory volume in 1 s percentage of predicted