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. 2021 May 13;268(12):4687–4697. doi: 10.1007/s00415-021-10575-w

Table 1.

The cerebellar cortical thickness profile of the ALS-FTD spectrum

Cerebellar lobule Cortical thickness: estimated marginal mean ± standard error (mm) Statistics
HC ALS-FTD-C9- ALS-FTD-C9 +  bvFTD nvfPPA svPPA F, p value Univariate effect size HC vs ALSFTDC9- HC vs ALSFTDC9 +  HC vs bvFTD HC vs nfvPPA HC vs svPPA
Left a I–II 1.416  ± 0.031 1.678  ± 0.074 1.437  ± 0.074 1.432  ± 0.124 1.604  ± 0.095 1.749  ± 0.190 F = 3.045, p = 0.012 η2p = 0.085 0.015 0.9 0.94 0.21 0.23
III 3.213  ± 0.035 3.355  ± 0.083 3.269  ± 0.083 3.058  ± 0.140 3.182  ± 0.107 3.501  ± 0.214 F = 1.198, p = 0.312 η2p = 0.035 0.26 0.73 0.47 0.9 0.36
IV 4.913  ± 0.014 4.930  ± 0.033 4.817  ± 0.033 4.788  ± 0.055 4.891  ± 0.042 4.919  ± 0.084 F = 2.462, p = 0.035 η2p = 0.070 0.82 0.06t 0.133 0.82 0.95
V 4.898  ± 0.015 4.875  ± 0.035 4.803  ± 0.034 4.796  ± 0.058 4.816  ± 0.045 4.873  ± 0.089 F = 2.095, p = 0.069 η2p = 0.060 0.73 0.072 0.23 0.23 0.9
VI 4.978  ± 0.011 4.917  ± 0.026 4.898  ± 0.026 4.907  ± 0.044 4.880  ± 0.034 4.975  ± 0.067 F = 3.431, p = 0.006 η2p = 0.095 0.15 0.05 0.26 0.06t 0.97
VIIB 4.608  ± 0.021 4.566  ± 0.049 4.476  ± 0.049 4.470  ± 0.082 4.408  ± 0.063 4.467  ± 0.125 F = 3.164, p = 0.009 η2p = 0.088 0.61 0.076 0.26 0.036 0.46
VIIIA 4.649  ± 0.018 4.662  ± 0.041 4.643  ± 0.041 4.502  ± 0.070 4.598  ± 0.053 4.637  ± 0.107 F = 1.023, p = 0.406 η2p = 0.030 0.9 0.94 0.168 0.54 0.94
VIIIB 4.514  ± 0.032 4.671  ± 0.076 4.430  ± 0.076 4.322  ± 0.129 4.711  ± 0.098 4.582  ± 0.196 F = 2.290, p = 0.048 η2p = 0.065 0.21 0.49 0.3 0.21 0.9
IX 3.570  ± 0.043 3.621  ± 0.101 3.398  ± 0.101 3.298  ± 0.170 3.715  ± 0.130 3.504  ± 0.260 F = 1.363, p = 0.241 η2p = 0.040 0.82 0.26 0.26 0.47 0.9
X 2.491  ± 0.042 2.299  ± 0.099 2.468  ± 0.098 2.273  ± 0.0166 2.609  ± 0.127 2.710  ± 0.254 F = 1.400, p = 0.227 η2p = 0.041 0.23 0.9 0.38 0.55 0.51
Crus I 4.575  ± 0.021 4.516  ± 0.049 4.377  ± 0.049 4.445  ± 0.083 4.405  ± 0.063 4.353  ± 0.126 F = 4.241, p = 0.001 η2p = 0.114 0.46 0.003 0.27 0.072 0.23
Crus II 4.365  ± 0.026 4.290  ± 0.062 4.097  ± 0.062 4.390  ± 0.104 4.090  ± 0.080 3.983  ± 0.159 F = 5.695, p < 0.001 η2p = 0.148 0.46 0.003 0.9 0.015 0.095
Rightb I–II 1.354  ± 0.029 1.636  ± 0.068 1.386  ± 0.068 1.462  ± 0.114 1.569  ± 0.087 1.587  ± 0.174 F = 3.878, p = 0.002 η2p = 0.106 0.001 0.85 0.56 0.09 0.4
III 3.092  ± 0.032 3.167  ± 0.076 3.118  ± 0.076 3.163  ± 0.128 3.142  ± 0.098 3.139  ± 0.196 F = 0.234, p = 0.947 η2p = 0.007 0.56 0.85 0.8 0.83 0.86
IV 4.772  ± 0.019 4.755  ± 0.045 4.714  ± 0.045 4.758  ± 0.076 4.819  ± 0.058 4.794  ± 0.116 F = 0.475, p = 0.795 η2p = 0.014 0.85 0.45 0.86 0.65 0.86
V 4.752  ± 0.018 4.679  ± 0.043 4.648  ± 0.043 4.686  ± .072 4.735  ± 0.055 4.703  ± 0.110 F = 1.399, p = 0.227 η2p = 0.041 0.26 0.11 0.56 0.85 0.85
VI 4.928  ± 0.011 4.880  ± 0.026 4.855  ± 0.026 4.883  ± 0.043 4.835  ± 0.033 4.901  ± 0.066 F = 2.768, p = 0.020 η2p = 0.078 0.23 0.054t 0.52 0.054t 0.85
VIIB 4.788  ± 0.017 4.695  ± 0.041 4.608  ± 0.041 4.610  ± 0.069 4.665  ± 0.053 4.399  ± 0.106 F = 6.938, p < 0.001 η2p = 0.175 0.14 0.001 0.07t 0.11 0.001
VIIIA 4.642  ± 0.017 4.600  ± 0.039 4.571  ± 0.039 4.522  ± 0.066 4.576  ± 0.050 4.448  ± 0.101 F = 1.849, p = 0.106 η2p = 0.053 0.52 0.24 0.23 0.44 0.18
VIIIB 4.573  ± 0.026 4.593  ± 0.061 4.497  ± 0.061 4.454  ± 0.103 4.519  ± 0.079 4.673  ± 0.157 F = 0.695, p = 0.628 η2p = 0.021 0.85 0.45 0.45 0.73 0.74
IX 3.763  ± 0.037 3.70  ± 0.088 3.609  ± 0.088 3.485  ± 0.148 3.720  ± 0.113 3.720  ± 0.226 F = 1.148, p = 0.337 η2p = 0.034 0.86 0.26 0.21 0.85 0.86
X 2.251  ± 0.036 2.105  ± 0.085 2.146  ± 0.085 1.996  ± 0.143 2.228  ± 0.110 2.170  ± 0.219 F = 1.127, p = 0.348 η2p = 0.033 0.26 0.45 0.23 0.86 0.85
Crus I 4.636  ± 0.022 4.572  ± 0.051 4.524  ± 0.051 4.393  ± 0.086 4.429  ± 0.066 4.157  ± 0.131 F = 5.628, p < 0.001 η2p = 0.146 0.45 0.15 0.047 0.03 0.001
Crus II 4.576  ± 0.024 4.499  ± 0.055 4.412  ± 0.055 4.381  ± 0.093 4.364  ± 0.071 4.035  ± 0.142 F = 5.637, p < 0.001 η2p = 0.147 0.41 0.047 0.15 0.043 0.001

Estimated marginal means ± S.E. for cortical thickness are adjusted for age and gender

aPillai’s Trace = 0.623; F (12,60) = 1.864; p < 0.001; η2p = 0.125;

bPillai’s Trace = 0.575; F (12,60) = 1.701; p = 0.001; η2p = 0.115; Bold p values are significant at p < 0.05, after false-discovery rate correction for multiple comparisons. Partial η2 effect size is interpreted as small (η2p = 0.01), medium (η2p = 0.06) or large (η2p = 0.14). t statistical trend at p ≤ 0.07