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. 2021 Apr 25;268(12):4667–4679. doi: 10.1007/s00415-021-10569-8

Table 2.

Baseline values with subgroup comparison (SMA type 2 versus SMA type 3)

SMA nBL nBL↑ nBL↓ Meana ± SDa Rangea p valueb
CSF

 WBC

(/µL)

 2 13c 1 n/a 2.3 ± 4.3 0–16
3 34c 2 n/a 2.4 ± 2.4 0–13
Total 47c 3 n/a 2.4 ± 3.0 0–16 0.15

 Glucose

(mg/dL)

 2 13c n/a 0 62.5 ± 5.8 53–72
3 34c n/a 0 65.7 ± 5.4 56–75
Total 47c n/a 0 64.8 ± 5.7 53–75 0.12

 Lactate

(mmol/L)

 2 13c 0 n/a 1.35 ± 0.19 1.0–1.7
3 34c 1 n/a 1.57 ± 0.27 1.1–2.5
Total 47c 1 n/a 1.51 ± 0.27 1.0–2.5 0.01

 Protein

(mg/dL)

 2 13c 1 0 34.1 ± 8.6 19–46
3 34c 11 0 41.9 ± 12.4 26–72
Total 47c 12 0 39.7 ± 11.9 19–72 0.07
Blood

 WBC

(/nL)

 2 13 2 0 7.2 ± 2.2 3.9–11.7
3 35 5 0 7.1 ± 1.8 4.6–11.9
Total 48 7 0 7.1 ± 1.9 3.9–11.9 0.94

 CRP

(mg/dL)

 2 13 5 n/a –  < 0.5–1.5
3 31 10 n/a –  < 0.5–2.3
Total 44 15 n/a –  < 0.5–2.3 0.68

 Platelets

(/nL)

 2 13 5 2 315.2 ± 122.0 103–477
3 35 0 0 265.9 ± 50.9 176–368
Total 48 5 2 279.3 ± 78.5 103–477 0.07
 INR 2 12 0 n/a 1.02 ± 0.06 0.92–1.12
3 16 1 n/a 1.02 ± 0.08 0.93–1.19
Total 28 1 n/a 1.02 ± 0.07 0.92–1.19 0.96

 aPTT

(s)

 2 12 0 n/a 28.8 ± 2.6 24.3–32.1
3 16 1 n/a 27.5 ± 3.1 20.9–32.9
Total 28 1 n/a 28.1 ± 2.9 20.9–32.9 0.29

 Crea

(mg/dL)

 2 13 0 13 0.31 ± 0.05 0.26–0.43
3 33 0 24 0.49 ± 0.14 0.28–0.78
Total 46 0 37 0.44 ± 0.15 0.26–0.78 0.0001

 Urea

(mg/dL)

 2 13 0 2 8.8 ± 4.1 4.0–18.0
3 33 3 1 11.9 ± 4.3 5.0–22.0
Total 46 3 3 11.0 ± 4.5 4.0–22.0 0.02

 AST

(U/L)

 2 13 0 n/a 21.0 ± 8.9 11–39
3 33 1 n/a 28.5 ± 13.1 11–72
Total 46 1 n/a 26.4 ± 12.4 11–72 0.07

 ALT

(U/L)

 2 13 2 n/a 31.5 ± 29.1 8–111
3 33 14 n/a 47.7 ± 24.2 17–118
Total 46 16 n/a 43.2 ± 26.4 8–118 0.01

 GGT

(U/L)

 2 13 2 n/a 36.1 ± 45.1 7–176
3 33 7 n/a 43.7 ± 39.3 7–190
Total 46 9 n/a 41.5 ± 40.7 7–190 0.14

CSF cerebrospinal fluid, SMA spinal muscular atrophy, WBC white blood cell count, CRP C-reactive protein, INR international normalized ratio, aPTT activated partial thromboplastin time, crea creatinine, urea urea nitrogen, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma-glutamyltransferase, nBL number of available baseline values, nBL↑ number of elevated baseline values, nBL↓ number of lowered baseline values, SD standard deviation, n/a not applicable (only medically reasonable or meaningful directions of deviation were considered)

aUnits as specified in the first column

bSMA type 2 versus SMA type 3

cThree CSF baseline samples were excluded from statistical analyses because of red blood cell contamination