Table 4.
Number of patients with shifts to abnormal laboratory values under therapy
| Baseline | Deviation from normal range under therapy | |||||
|---|---|---|---|---|---|---|
| Normal | Dir | Sporadica | Transientb | Persistentc | No deviation | |
| CSF | ||||||
| WBC | 44 |
⬈ ⬊ |
7 (15.9%) n/a |
2 (4.5%) n/a |
0 (0.0%) n/a |
35 (79.5%) |
| Glucose | 47 |
⬈ ⬊ |
n/a 0 (0.0%) |
n/a 0 (0.0%) |
n/a 0 (0.0%) |
47 (100%) |
| Lactate | 46 |
⬈ ⬊ |
3 (6.5%) n/a |
1 (2.2%) n/a |
0 (0.0%) n/a |
42 (91.3%) |
| Protein | 35 |
⬈ ⬊ |
6 (17.1%) n/a |
3 (8.6%) n/a |
2 (5.7%) n/a |
24 (68.6%) |
| Blood | ||||||
| WBC | 41 |
⬈ ⬊ |
7 (17.1%) 1 (2.4%) |
0 (0.0%) 0 (0.0%) |
1 (2.4%) 0 (0.0%) |
32 (78.0%) |
| CRP | 29 |
⬈ ⬊ |
9 (31.0%) n/a |
3 (10.3%) n/a |
0 (0.0%) n/a |
17 (58.6%) |
| Platelets | 41 |
⬈ ⬊ |
1 (2.4%) 1 (2.4%) |
1 (2.4%) 0 (0.0%) |
0 (0.0%) 0 (0.0%) |
38 (92.7%) |
| INR | 27 |
⬈ ⬊ |
2 (7.4%) n/a |
0 (0.0%) n/a |
0 (0.0%) n/a |
25 (92.6%) |
| aPTT | 27 |
⬈ ⬊ |
4 (14.8%) n/a |
0 (0.0%) n/a |
0 (0.0%) n/a |
23 (85.2%) |
| Crea | 9 |
⬈ ⬊ |
0 (0.0%) 2 (22.2%) |
0 (0.0%) 3 (33.3%) |
0 (0.0%) 1 (11.1%) |
3 (33.3%) |
| Urea | 40 |
⬈ ⬊ |
3 (7.5%) 3 (7.5%) |
0 (0.0%) 0 (0.0%) |
0 (0.0%) 0 (0.0%) |
34 (85.0%) |
| AST | 45 |
⬈ ⬊ |
2 (4.4%) n/a |
1 (2.2%) n/a |
1 (2.2%) n/a |
41 (91.1%) |
| ALT | 30 |
⬈ ⬊ |
2 (6.7%) n/a |
1 (3.3%) n/a |
0 (0.0%) n/a |
27 (90.0%) |
| GGT | 37 |
⬈ ⬊ |
0 (0.0%) n/a |
2 (5.4%) n/a |
1 (2.7%) n/a |
34 (91.9%) |
CSF cerebrospinal fluid, WBC white blood cell count, CRP C-reactive protein, INR international normalized ratio, aPTT activated partial thromboplastin time, crea creatinine, urea urea nitrogen, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT gamma-glutamyltransferase, Dir direction, ⬈, increased/elevated, ⬊ decreased/lowered, n/a not applicable (only medically reasonable or meaningful directions of deviation were considered)
aOnly singular deviations from the normal range with immediate normalization afterwards
bTwo or more deviations in a row with normalization afterwards or two deviations in a row at the end of the observation period
cThree or more deviations in a row without normalization until the end of the observation period