Fig. 1.

Confidence in evidence for antipsychotic drugs compared to placebo in terms of 13 outcome measures. White bars indicate the percentage of outcomes for which not a single RCT was available (figure reproduced with permission from Huhn et al. 2019 [5]). In this figure published in Huhn et al. 2019 [5] for every antipsychotic drug the percentage of outcomes with the following evidence levels was presented: high = blue, moderate = green, low = orange, very low = red according to CINeMA (Confidence in Network Meta-analysis). If outcomes were not reported in at least a single trial, we added them as “not available” in white. Benperidol, a frequently used drug in Germany, was added. The following 13 outcomes were used: overall symptoms, positive symptoms, negative symptoms, depression, all-cause discontinuation, quality of life, functioning, weight gain, use of anti-Parkinson medication, akathisia, sedation, QTc prolongation and prolactin increase