Table 1.
Clinical characteristics of participants at baseline and follow-up
| Variable | Rivaroxaban (n=89) | Aspirin (n=90) | Comparison of groups | ||
|---|---|---|---|---|---|
| Baseline | Week 20 | Baseline | Week 20 | ||
| Age (years) | 64.2 ± 7.4 | 64.7 ± 6.8 | |||
| Sex (m/f) | 38/51 | 46/44 | |||
| Diabetes duration (years) | 9.2 ± 5.1 | 9.2 ± 5.2 | |||
| BMI (kg/m2) | 33.2 ± 5.3 | 33.4 ± 5.1 | |||
| Syst BP (mmHg) | 134 ± 13 | 133 ± 13 | 132 ± 13 | 134 ± 13 | −2.12 (−5.65, 1.42) |
| Diast BP (mmHg) | 83 ± 9 | 81 ± 8 | 83 ± 10 | 82 ± 9 | −1.21 (−3.47, 1.04) |
| HbA1c (mmol/mol) | 51.4 ± 6.0 | 51.4 ± 6.8 | 52.4 ± 7.5 | 51.0 ± 5.6 | 0.664 |
| HbA1c (%) | 6.9 ± 0.8 | 6.9 ± 0.9 | 6.9 ± 1 | 6.8 ± 0.8 | |
| LDL-C (mmol/l) | 3.3 ± 0.9 | 3.5 ± 0.9† | 3.3 ± 1.0 | 3.4 ± 0.8 | 0.2 (0.01, 0.38) |
| eGFR (ml/min) | 98.8 ± 24.2 | 98.8 ± 25 | 95.5 ± 23.3 | 95.5 ± 23.1 | 0.944 |
| UACR (mg/mmol) | 2.9 ± 5 | 3.0 ± 6.5 | 3.8 ± 7.4 | 3.1 ± 7.3 | 0.817 |
| Prothrombin time (%) | 103.7 ± 9.5 | 81.4 ± 17.6* | 101.4 ± 12.1 | 103.5 ± 11.4 | <0.001 |
| aPTT (s) | 29.5 ± 2.02 | 33.2 ± 3.9† | 29.7 ± 2.4 | 29.5 ± 2 | 3.92 (3.15, 4.69) |
| PTF 1+ 2 (pmol/l) | 204 ± 89.9 | 173.2 ± 256.8* | 211.3 ± 233.2 | 206.5 ± 106 | <0.001 |
| T/AT III (ng/ml) | 6 ± 8.2 | 5.3 ± 8.3 | 9.5 ± 12.1 | 6.7 ± 10.1 | 0.743 |
| D-dimer (ng/ml) | 413.6 ± 212.6 | 418.5 ± 455.3* | 412.8 ± 243.8 | 415.1 ± 236.2 | 0.066 |
| von Willebrand factor (%) | 152.2 ± 57.9 | 151.9 ± 56.5 | 148.4 ± 55.9 | 147 ± 54.8 | 0.710 |
| Fibrinogen (g/l) | 3.5 ± 0.7 | 3.7 ± 0.9 | 3.7 ± 0.7 | 3.6 ± 0.7 | 0.05 (0, 0.09)a |
| Protein C (%) | 124.1 ± 20.5 | 123.6 ± 22.7 | 119.8 ± 21.4 | 118.2 ± 19.6 | 0.711 |
| Protein S (%) | 113.7 ± 22.5 | 110.8 ± 25.1* | 109.7 ± 21.5 | 107.8 ± 17.8 | 0.120 |
| Hematocrit (%) | 41.1 ± 3.3 | 40.6 ± 3.0 | 41.2 ± 3.5 | 41.1 ± 3.5 | 0.02 (−0.03, 0.06)a |
Comparison between groups (based on intraindividual differences between week 20 and baseline): effect size and 95% CI are given for ANCOVA or p values for Mann–Whitney U test
aTest on log-transformed data
Comparison vs baseline: *<0.02 (Wilcoxon’s signed rank test); †<0.02 (paired t test)
aPTT, activated partial thromboplastin time; diast BP, diastolic BP; LDL-C, LDL-cholesterol; m/f, male/female; syst BP, systolic BP; T/AT, thrombin/antithrombin III complex; UACR, urinary albumin/creatinine ratio