Table 2.

Summary of omnibus univariate PERMANOVA tests using features from beta diversity metrics and clinical indices in children with ASD aged older than 4 years.

Clinical index	Univariate	Univariate	Multivariate	Multivariate	Multivariate
	R2 (%)	P-value	F-statistic (df = 1)	R2 (%)	P-value
Bray-Curtis
CARS overall score	14.512	0.045	1.460	0.043	NS
Intestinal irritability	9.795	0.029	3.459	0.101	0.011*
Fatigue	8.143	0.050	1.841	0.054	0.095.
SRS cognition (range T)	13.311	0.015	5.388	0.158	0.004**
Restricted interests	8.215	0.048	1.1346	0.033	NS
Unweighted UniFrac
GIS total score	7.500	0.033	2.345	0.075	0.011*
Constipation	8.149	0.019	1.393	0.045	NS
Abdominal pain	11.257	0.001	3.313	0.106	0.002**
Fatigue	7.706	0.025	1.732	0.055	0.064
Weighted UniFrac
CARS overall score	14.830	0.039	0.902	0.032	NS
SRS cognition (range T)	9.131	0.038	2.783	0.099	0.015*
Restricted interests	8.013	0.039	1.464	0.052	NS

^* P < 0.05;

^**P < 0.005.