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. 2021 Nov 2;12:6304. doi: 10.1038/s41467-021-26539-7

Fig. 6. The prophylactic efficacy of 58G6 or 510A5 in hACE2 transgenic mice challenged with authentic viruses.

Fig. 6

a Body weight changes were recorded for PBS (SARS-CoV-2 (WIV04): n = 5; B.1.351: n = 6), 58G6 (SARS-CoV-2 (WIV04): n = 4; B.1.351: n = 7) and 510A5 (SARS-CoV-2 (WIV04): n = 5; B.1.351: n = 7) treatment groups. All the mice received one dose of antibodies (10 mg/kg body weight) injected (i.p.) 24 h prior to the intranasal challenge with SARS-CoV-2 (WIV04) (left) or B.1.351 (right). Equal volume of PBS was used as negative control. The weight loss was recorded over a course of 3 days. b The virus loads in infected lungs of the PBS group, the 58G6 group and the 13G9 group as shown in a were determined by PRNT at 3 days post infection (dpi). The mean values ± SEM of all data points were shown. p values were calculated via two-sided Student’s t-test. Dashed line indicated assay limits of detection (LOD).