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. 2021 Nov 2;11:21425. doi: 10.1038/s41598-021-00954-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Results of cell cycle test of MDA-MB-231 cells treated with all formulations (0.259 μg/mL of B2D, 2D, BD, Dox, BC and Conf and 2.59 μg/mL of PB) by flowcytometry method: (A) Histograms of cell cycle distrubution and (B) Quantitative diagram of cell population (%) in different phases of cell cycle (Sub G1, G0/G1, S and G2/M), in presence of all formulations (Abbreviations: PB: blank βCD-g-PMA-co-PLGA micelles, B2D: co-drug loaded βCD-g-PMA-co-PLGA micelles, BD: Dox loaded βCD-g-PMA-co-PLGA micelles, BC: Conferone loaded βCD-g-PMA-co-PLGA micelles, Dox: Free Doxorubicin, Conf: Free Conferone, 2D: Free Doxorubicin-Conferone).