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. 2021 May 20;28(11):3077–3091. doi: 10.1038/s41418-021-00803-1

Fig. 6. TRIM26 deficiency protects mice from LPS-induced septic shock.

Fig. 6

A Sex- and age-matched Trim26+/+ and Trim26–/– mice (n = 6) were injected intraperitoneally with LPS (40 μg/g) for 4 h. ELISA analysis of TNF-α, IL-6, and IL-12p40 in the serum of Trim26+/+ and Trim26–/– mice. B Trim26+/+ and Trim26–/– littermates (n = 12) were stimulated with LPS (40 μg/g) as in A. The survival of mice was monitored over the following 5 days. C Trim26+/+ and Trim26–/– mice were injected intraperitoneally with LPS (40 μg/g) for 4 h, H&E experiments were performed on the lung injury of the mice. D Histological analysis of colon tissues described in C. Scale bars, 100 μm. Data are shown as mean ± SD in A; n = 6 biologically independent animals. *p < 0.05, **p < 0.01; A Student’s t test; B log-rank t-est. Similar results were obtained in three independent experiments.