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. 2021 Oct 20;12:739757. doi: 10.3389/fimmu.2021.739757

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Copyright © 2021 Agrawal, Salazar, Tran and Agrawal

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Irradiated SARS-CoV-2 is a better inducer of cytotoxic T lymphocytes than heat-inactivated SARS-CoV-2. PBMCs stimulated with irradiated SARS-CoV-2 (IRR) or heat-inactivated (HI) or Vero cell lysate (Vero) were cultured for 7 days. Cells collected were stained for CD8, perforin, and granzyme B and acquired on a flow cytometer. (A) Gating strategy for the identification of these cells. (B) Dot plot depicts the % of cytotoxic CD8 T cells. (C) Quantitation of cytokines/chemokines in the supernatant by multiplex. Mean ± SE. N = 12 subjects. p-value was calculated using one-way ANOVA followed by Tukey’s test.