Figure 2 .

Two pairwise comparisons shed light on PARIS-driven global expression changes in fly DA neurons. (a-b) Only “TRAP control versus PARIS wild type” and “PARIS C571A mutant versus PARIS wild type” pairwise comparisons with a special focus on transcriptional suppression generated biologically meaningful outcome. (c) A Venn diagram¹⁹ showing only for these two comparisons mentioned here majority of the DEGs that are downregulated are comparison-specific, not shared as in the rest of the comparisons. (d) Functional enrichment results of 686 DEGs identified as downregulated from the “TRAP control versus PARIS wild type” comparison, implying mitochondrial dysfunction underlying PARIS phenotype.