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. 2021 Nov 2;11:21536. doi: 10.1038/s41598-021-01064-1

Table 1.

Baseline characteristics of study cohorts.

Characteristic Study individuals, no. (%)
Cohort 1 (n = 5580) Cohort 2 (n = 6057) Cohort 3 (n = 7249)
Testing year compared 2018 vs. 2017 2019 vs. 2018 2020 vs. 2019
Group 1: individuals whose vitamin D increased by ≥ 10 ng/mLa 3246 (58.2) 2820 (46.6) 4393 (60.6)
Group 2: individuals whose vitamin D decreased by ≥ 10 ng/mLa 2334 (41.8) 3237 (53.4) 2856 (39.4)
Age, years
Median (IQR) 48 (38–56) 48 (38–56) 49 (39–57)
Sex
Male 1674 (30.0) 1837 (30.3) 2215 (30.6)
Female 3906 (70.0) 4220 (69.7) 5034 (69.4)
Race/ethnicity
Asian 684 (15.6) 726 (15.4) 1209 (17.0)
Black 995 (22.7) 1094 (23.2) 1323 (18.6)
Hispanic 539 (12.3) 643 (13.6) 801 (11.2)
Otherb 30 (0.7) 29 (0.6) 585 (8.2)
White 2128 (48.6) 2232 (47.2) 3212 (45.0)
Education
No college degree 2618 (47.8) 2818 (47.4) 3234 (46.4)
College degree 2862 (52.2) 3128 (52.6) 3730 (53.6)
Body mass index (kg/m2)
≥ 30 1925 (34.5) 2154 (35.6) 2525 (34.9)
< 30 3653 (65.5) 3896 (64.4) 4717 (65.1)
Blood pressure
High 2417 (43.3) 2606 (43.1) 3098 (42.8)
Elevated 817 (14.6) 938 (15.5) 1156 (16.0)
Normal 2343 (42.0) 2505 (41.4) 2987 (41.3)
Smoking
Yes 554 (9.9) 709 (11.7) 813 (11.2)
No 5025 (90.1) 5348 (88.3) 6427 (88.8)
Geographical location
Northeast 1056 (18.9) 1151 (19.1) 1409 (19.5)
Midwest 1020 (18.3) 1083 (18.0) 1256 (17.4)
West 1132 (20.3) 1201 (19.9) 1504 (20.8)
South 2372 (42.5) 2593 (43.0) 3051 (42.3)
Vitamin D, ng/mL
Median (IQR) 32 (23–44) 34 (24–46) 32 (23–42)
Lipid levels, mg/dL, median (IQR)
TC 184 (160–209) 183 (161–208) 184 (161–209)
LDL-C 107 (86–129) 106 (85–127) 108 (86–129)
HDL-C 54 (44–66) 54 (45–66) 54 (46–65)
TG 97 (69–136) 94 (68–136) 95 (69–134)

IQR: interquartile range; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides.

aComparisons of baseline characteristics between these two groups are reported in Tables S1, S2 and S3.

bAmerican Indian or Alaska Native, Native Hawaiian or other Pacific Islander, or 2 or more ethnicities.