Table 2.
Changes in lipid levels according to changes in vitamin D levels.
| Lipid | Study cohorta | Change in lipid levels mean ± SD, mg/dL | Unadjusted difference in the change in lipid levels (95% CI), mg/dLb | Unadjusted P value | |
|---|---|---|---|---|---|
| Vitamin D increased by ≥ 10 ng/mL (group 1) | Vitamin D decreased by ≥ 10 ng/mL (group 2) | ||||
| TC | |||||
| 1 | − 5.80 ± 30.52 | 6.22 ± 27.86 | 12.02 (10.46–13.59) | < 0.001 | |
| 2 | − 5.70 ± 30.54 | 5.98 ± 28.79 | 11.58 (10.09–13.08) | < 0.001 | |
| 3 | − 2.74 ± 28.49 | 7.96 ± 28.20 | 10.71 (9.37–12.05) | < 0.001 | |
| LDL-C | |||||
| 1 | − 5.36 ± 25.85 | 3.22 ± 23.64 | 8.59 (7.26–9.91) | < 0.001 | |
| 2 | − 3.75 ± 26.21 | 4.69 ± 23.96 | 8.43 (7.17–9.70) | < 0.001 | |
| 3 | − 2.24 ± 24.36 | 5.18 ± 23.80 | 7.42 (6.28–8.55) | < 0.001 | |
| HDL-C | |||||
| 1 | 1.14 ± 9.66 | 0.74 ± 9.52 | − 0.40 (− 0.91–1.11) | 0.13 | |
| 2 | 0.02 ± 9.06 | − 0.46 ± 9.57 | − 0.48 (− 0.01 to − 0.95) | 0.05 | |
| 3 | 0.10 ± 7.95 | 0.41 ± 8.77 | 0.31 (− 0.08 to 0.70) | 0.12 | |
| TG | |||||
| 1 | − 11.59 ± 51.47 | 16.50 ± 62.59 | 28.09 (25.09–31.09) | < 0.001 | |
| 2 | − 14.07 ± 57.71 | 12.55 ± 48.99 | 26.62 (23.93–29.30) | < 0.001 | |
| 3 | − 4.56 ± 51.23 | 17.03 ± 61.79 | 21.59 (18.97–24.21) | < 0.001 | |
TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglycerides; CI: confidence interval; SD: standard deviation.
aCohort 1: 2018 versus 2017; cohort 2: 2019 versus 2018; cohort 3: 2020 versus 2019.
bDifference between group 2 and group 1.