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. 2021 Aug 31;42(11):1808–1820. doi: 10.1038/s41401-021-00754-w

Fig. 8. The anti-hepatic fibrosis mechanism of PPZ.

Fig. 8

PPZ disrupted the interaction between OTUB2 and YAP, thereby promoting YAP degradation. The increase of YAP degradation further restrained the nuclear translocation of YAP, disrupted the YAP/TEAD2 interaction, and inhibited the transcription of downstream target genes exerting a repressive effect on liver fibrosis.