Fig. 8. The anti-hepatic fibrosis mechanism of PPZ.
PPZ disrupted the interaction between OTUB2 and YAP, thereby promoting YAP degradation. The increase of YAP degradation further restrained the nuclear translocation of YAP, disrupted the YAP/TEAD2 interaction, and inhibited the transcription of downstream target genes exerting a repressive effect on liver fibrosis.