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The bZIP domain of CREB-2 cooperates with Tax to activate a luciferase gene reporter driven by a synthetic promoter containing three tandem copies of either the HTLV-1 promoter-proximal TxRE (A) or the cellular palindromic CRE site (B). CEM cells were cotransfected as described for Fig. 1 but pCI-CREB-2 was replaced by 0.5 μg of pCDM7-CREB-2262-351. Values are the means ± standard deviation (n = 3).
