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. 2021 Oct 20;9:740455. doi: 10.3389/fcell.2021.740455

FIGURE 1.

FIGURE 1

Hierarchical clustering and analysis of the genome stable (GS)-like and genome unstable (GU)-like clusters. (A) The heatmap of 123 genome instability-related lncRNAs (GIRlncRs) between the GS and GU groups. (B) The coexpression network of the GIRlncRs and top-10 correlated mRNAs for each lncRNAs by Pearson’s correlation. The functional enrichment analysis of the coexpressed mRNAs of GIRlncRs based on GO (C) and KEGG (D). (E) The unsupervised hierarchical clustering based on 123 genome instability-related lncRNAs. The comparison of the tumor mutational burden (F), microsatellite instability (G), expression of six immune checkpoint-related genes (CD274 (PD-L1), CD80, PDCD1 (PD-1), PDCD1LG2(PD-L2), CD86, and CTLA4) (H), expression and mutation rate of four DNA mismatch repair protein gene (MLH1, MSH2, MSH6, and PMS2) (I) and mutation rate of POLE (L) between the two clusters by Mann-Whitney U test. The comparison of the immune cell infiltration (J) and Immune functions (K) of the two clusters by ssGSEA. (M) The survival analysis of the two clusters by log-rank test. *p < 0.05; ***p < 0.001; and ns, not significant.