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. 2021 Oct 20;9:740455. doi: 10.3389/fcell.2021.740455

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Copyright © 2021 Ren, Wang, Gu, Ma, Zhu, Cai and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of mutation profile and identification of hub-lncRNAs in genome stable (GS)- and genome unstable (GU)-like clusters. (A) Sankey plot of the relationship among GS- and GU-like clusters, risk groups, and survival status. The mutation profile of GS-like cluster (B) and GU-like cluster (C). (D) The selection of λ in least absolute shrinkage and selection operator regression. (E) The selection of L1 norm in LASSO regression. (F) The Venn plot of hub-lncRNA in SVM (support vector machine), LASSO, or prognostic signature. (G) Screening process of the lncRNA, miRNA, mRNA included in the ceRNA network.